MRI of
extensive clival chordoma in 17-year-old male patient, axial view. Tumor in the
nasopharynx extending from nasal cavity to brainstem posteriorly is clearly
visible. (Credit: wikipedia.org)
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Chordoma is a rare slow-growing neoplasm thought
to arise from cellular remnants of the notochord.
The evidence for this is the location of the tumors (along the neuraxis), the
similar immunohistochemical staining patterns, and the demonstration that
notochordal cells are preferentially left behind in the clivus and sacrococcygeal regions when the
remainder of the notochord regresses during fetal life.